Table 2.
Comparison of multiple indices in refined lesion segmentation. a) One-way ANOVA shows significant change in rCBF, pH and ADC among ADC lesion, pH/ADC and PWI/pH mismatch. b) One-way ANOVA shows pH resolves all three regions: ADC lesion, pH/ADC mismatch and PWI/pH mismatch while rCBF and ADC have limited ability to refine the lesion zones.
| a | ||||
|---|---|---|---|---|
| DWI lesion (Area I) |
pH/DWI mismatch (Area IIa) |
PWI/pH mismatch (Area IIb) |
One-way ANOVA F (P value) |
|
| rCBF | 0.51 ± 0.11 | 0.56 ± 0.14 | 0.62 ± 0.11 | 4.24 (0.019*) |
| ADC(µm2/ms) | 0.64 ± 0.04 | 0.83 ± 0.05 | 0.84 ± 0.05 | 128.07 (<0.001*) |
| ΔMRAPTR (%/s) | −1.05 ± 0.29 | −0.67 ± 0.27 | −0.04 ± 0.14 | 89.17 (<0.001*) |
| b | |||
|---|---|---|---|
| DWI lesion vs. pH/DWI mismatch (Areas I vs. IIa) Mean Difference (P value) |
DWI lesion vs. PWI/pH mismatch (Areas I vs. IIb) Mean Difference (P value) |
PWI/pH vs. pH/DWI mismatch (Areas IIa vs. IIb) Mean Difference (P value) |
|
| rCBF | 0.05 (0.370) | 0.11 (0.01*) | 0.06 (0.274) |
| ADC(µm2/ms) | 0.18 (<0.001*) | 0.20 (<0.001*) | 0.02 (0.490) |
| ΔMRAPTR (%/s) | 0.37 (<0.001*) | 1.01(<0.001*) | 0.63 (<0.001*) |