Table II.

Markers of injury and DAMPs measured in BAL fluid at 6 hours after instillation of PBS or S. pneumoniae (SP) in WT or Nrf2 null mice

Analyte	WT			Nrf2 null
	PBS (n=7)	S. pneumoniae 2.36 ± 0.048 × 106 CFU per mouse (n=5)	S. pneumoniae 5.82 ± 0.43 × 107 CFU per mouse (n=8)	PBS (n=7)	S. pneumoniae 2.16 ± 0.036 × 106 CFU per mouse (n=5)	S. pneumoniae 5.14 ± 0.31 × 107 CFU per mouse (n=11)
Protein (μg/mL)	110 ± 7.9	165 ± 14	3296 ± 436 *	121 ± 11	178 ± 38	3552 ± 363 *
dsDNA (ng/mL)	12 ± 2.1	25 ± 6.0	92 ± 13 *	13 ± 3.1	22 ±4.2	66 ± 6.3 *
sICAM-1 (ng/mL)	101 ± 10	144 ± 9.1	184 ± 11 *	122 ± 12	162 ± 9.5	182 ± 7.8 *
S100A8 (pg/mL)	1109 ± 243	5571 ± 1257	41,812 ± 4870*	5215 ± 2107	10,171 ± 2969	26150 ± 2530 *,†
RAGE (pg/mL)	310 ± 30	664 ± 285	5305 ± 938 *	396 ± 23	589 ± 82	5753 ± 623 *
S100A9 (pg/mL)	2102 ±392	6316 ± 1001	48,738 ± 5690 *	5404 ± 1605	9732 ± 1761	32,117 ± 3370 *,†

Values are mean ± SEM. The number of samples in each group (n) is shown in the column subheadings.

^*, significantly different compared with PBS control of the same genotype;

^†, significantly different compared with WT mice that received the same treatment (p≤0.05, ANOVA and Tukey-Kramer HSD post hoc test).