Table V.

Differentially expressed genes (DEGs) in whole lung tissue and lung neutrophils from WT and Nrf2 null mice given PBS or S. pneumoniae

Tissue	DEG group	DEG
Whole lung tissue	DEGs in both PBS and S. pneumoniae-treated samples (23)	Acox2, Adh7, Akr1b8, Aldh3a1, Aox1, Cbr3, Cyp4f39, Gm21075, Gm21158, Gm2163, Gm3776, Gm3893, Gm8074, Gsta1, H60c, Igh-VJ558, LOC100041536, LOC100861727, LOC100862324, LOC102640144, Nqo1, Slc7a11, Srxn1
	DEGs in S. pneumoniae-treated samples only (24)	Aldh1l2, Ccl27a, Gm15247, Gm17046, Gm21320, Ighg2b, Ighg2c, Ighv1-76, Ighv1-83, Igh-V3660, Igj, Igkv1-117, Igkv8-30, LOC435333, Mup1, Mup10, Mup13, Mup16, Mup2, Mup7, Mup8, Tcrg-V6, Trgj1, U90926
	DEGs in PBS-treated samples only (30)	Abcc4, Acsm1, Angptl4, Arntl, B4galnt2, Bdkrb1, Cd177, Ces1g, Clec4e, Cyp2a5, Eid3, G530011O06Rik, Gclc, Gm10639, Gm19950, Gsta3, Gsta4, Hmox1, Il1f9, Ly6g6c, Mthfd1l, Npas2, Osgin1, Procr, Ptgs2, Sectm1b, Slc6a15, Tigit, Tsku, Txnrd1
Lung neutrophils	DEGs in both PBS and S. pneumoniae-treated samples(3)	Gm2163, Gm3893, LOC100041536
	DEGs in S. pneumoniae-treated samples only (20)	2210417A02Rik, Fap, Gclm, Gm13657, Gm17046, Gm21075, Gsta3, Heatr9, Ikbkg, LOC102631757, LOC102640720, Nqo1, Olfr1394, Olfr1395, Pf4, Rnf128, Slc22a1, Slc22a4, Srxn1, Tma16
	DEGs in PBS-treated samples only (1)	Ces1g
Whole lung tissue and neutrophils	DEGs in PBS and S. pneumoniae-treated samples (3)	Gm2163, Gm3893, LOC100041536
	DEGs in S. pneumoniae-treated samples only (1)	Gm17046
	DEGs in PBS-treated samples only (1)	Ces1g

Gene expression levels were compared between genotypes in mice given S. pneumoniae and in those given PBS as described in the text (Approach 1). Underlined genes are expressed at least 2 fold greater in Nrf2 null samples compared with WT; the rest are expressed 2 fold or greater in WT compared with Nrf2 null. The numbers in parentheses indicate the number of DEGs in each category.