Table VI.
DEGs in whole lung tissue and lung neutrophils from WT and Nrf2 null mice given PBS and/or S. pneumoniae
| Gene Symbol |
Description | Fold change in Nrf2 null compared to WT | |||
|---|---|---|---|---|---|
| Lung Tissue | Neutrophils | ||||
| SP | PBS | SP | PBS | ||
| Ces1g | carboxylesterase 1G (NM 021456) |
−1.6 | −12.8* | −1.0 | −8.3* |
| Gm17046 | predicted gene 17046 (ENSMUST00000168078) |
−2.3* | −1.9 | −2.9* | −1.2 |
| Gm21075 | predicted gene, 21075 (XR_390710) |
−8.9* | −7.9* | −4.1* | −4.5 |
| Gm2163 |
predicted gene 2163
(XR_390501) |
−6.0* | −5.0* | −2.8* | −3.5* |
| Gm3893 |
predicted gene 3893
(NR_033506) |
−8.9* | −7.4* | −4.0* | −5.0* |
| Gsta3 | glutathione S-transferase, alpha 3 (NM_001077353) |
−3.0 | −3.1* | −4.6* | −1.3 |
|
LOC1000
41536 |
protein FAM205A-like (XR
390020) |
−6.1* | −5.0* | −2.6* | −3.6* |
| Nqo1 | NAD(P)H dehydrogenase, quinone 1 (NM 008706) |
−4.9* | −4.5* | −11.1* | −3.8 |
| Srxn1 | sulfiredoxin 1 homolog (S. cerevisiae) (NM 029688) |
−2.9* | −3.2* | −4.5* | −2.3 |
Differentially expressed genes (DEGs) in bold type are significantly differentially expressed in both lung tissue and lung neutrophils given either PBS or SP.
*
, significantly differentially expressed in Nrf2 null compared to WT (fold change > 2 and FDR<0.05).