Table VIII.
Biological pathways and processes that are significantly enriched in WT compared to Nrf2 null lungs during S. pneumoniae pneumonia
| Gene Set ID | Description | Numb er of genes |
Enric hmen t Score |
Norm alized Enric hmen t Score |
FDR |
|---|---|---|---|---|---|
| Detoxification and antioxidant pathways | |||||
| REACTOME 7099083 |
Glutathione conjugation | 27 | −0.82 | −2.38 | 0.00 |
| KEGG MMU00480 | Glutathione metabolism | 51 | −0.71 | −2.35 | 0.00 |
| GO0004364 | Glutathione transferase activity | 28 | −0.76 | −2.29 | 0.00 |
| REACTOME 7098590 |
Phase II conjugation | 69 | −0.64 | −2.25 | 0.00 |
| GO0016765 | Transferase activity, transferring alkyl or aryl (other than methyl) groups |
55 | −0.67 | −2.24 | 0.00 |
| KEGG MMU00982 | Drug metabolism - cytochrome P450 | 54 | −0.67 | −2.23 | 0.00 |
| KEGG MMU00980 | Metabolism of xenobiotics by cytochrome P450 |
52 | −0.68 | −2.27 | 0.00 |
| BIOCYC MOUSE_PWY- 4061 |
glutathione-mediated detoxification | 22 | −0.78 | −2.16 | 0.00 |
| KEGG MMU05204 | Chemical carcinogenesis | 76 | −0.59 | −2.14 | 0.00 |
| WIKIPATHWAYS WP1245 |
Keap1-Nrf2 | 13 | −0.83 | −2.02 | 0.02 |
| GO0016903 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors |
50 | −0.62 | −2.06 | 0.03 |
| GO0006749 | Glutathione metabolic process | 46 | −0.66 | −2.15 | 0.05 |
| WIKIPATHWAYS WP164 |
Glutathione metabolism | 17 | −0.74 | −1.93 | 0.06 |
| REACTOME 7099084 |
Sulfur amino acid metabolism | 20 | −0.72 | −1.92 | 0.06 |
| GO1900750 | Oligopeptide binding | 15 | −0.77 | −1.98 | 0.07 |
| Immune cell signaling | |||||
| REACTOME 7099241 |
Generation of second messenger molecules | 22 | −0.75 | −2.10 | 0.00 |
| GO0042101 | T cell receptor complex | 13 | −0.83 | −2.05 | 0.04 |
| GO0001772 | Immunological synapse | 31 | −0.66 | −1.98 | 0.06 |
| KEGG MMU05340 | Primary immunodeficiency | 35 | −0.61 | −1.89 | 0.09 |
| Olfactory processes | |||||
| KEGG_MMU0474 0 |
Olfactory transduction | 1057 | −0.41 | −1.98 | 0.03 |
| GO0004984 | Olfactory receptor activity | 1083 | −0.42 | −2.01 | 0.06 |
| GO0005549 | Odorant binding | 453 | −0.44 | −1.99 | 0.06 |
GSEA was used to identify gene sets that show statistically significant, concordant differences in expression between WT and Nrf2 null lungs during S. pneumoniae pneumonia (FDR < 0.1). . The table lists the biological pathways or processes showing enrichment in WT compared to Nrf2 null lungs during pneumonia, sorted by functional categories. The genes that contributed to core enrichment are listed in Supplemental Table II.