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Relationship between gastric mucosae methylation levels and Helicobacter pylori infection/gastric cancer (modified from Maekita et al[22]). Residual aberrant methylation even after eradication is thought to reflect methylation in gastric gland stem cells. From endoscopically biopsied tissue, predicting GC risk based on the accumulation of aberrant DNA methylation in the gastric mucosae. ESD: Endoscopic submucosal resection; GC: Gastric cancer; H. pylori: Helicobacter pylori.
