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Structure and integrity of the proteins. Electron microscopy images of RV VP6 nanotubes (a), trimeric VP6 (b), and NoV GII.4 VLPs (c). Protein products were examined by FEI Tecnai F12 electron microscope (Philips Electron Optics, Holland) following negative staining with 3% uranyl acetate, pH 4.6. Bar 100 nm. Images observed at 9300x (a and b) and 11,000x (c) magnification.
