Table 1.

Comparison of additive models with and without non-linear interactions between candidate gene pairs in CATHGEN

	Additive Model	Interactive Model
Number of pairs	1120	677
Number of candidate genes	20	38

Number of significant pairs defined as having one or both RNAs associated with MI (p < 0.05) and number candidate genes forming those pairs. Shown for an additive versus interactive model. Additive model: MI as explained by main effects of candidate genes (logit(MI) ~ RNA1 + RNA2 + additional covariates). Interactive model: MI as explained by main effects of candidate genes and an interaction term (logit(MI) ~ RNA1 + RNA2 + RNA1*RNA2 + additional covariates)