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editorial

. 2016 Sep 15;194(6):655–656. doi: 10.1164/rccm.201603-0592ED

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Copyright © 2016 by the American Thoracic Society

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Figure 1. — Defective bone morphogenetic protein receptor type 2 (BMPR2) signaling effects on right ventricle (RV) myocytes. Aberrant BMPR2 signaling is associated with increased CD36 sarcolemma expression (independent of the effects of increased RV afterload in pulmonary hypertension), contributing to long-chain fatty acid (LCFA) accumulation and lipotoxicity, resulting in RV decompensation. In addition, disordered BMPR2 signaling is associated with impaired fatty acid oxidation (FAO), which could be associated with RV compensation in pulmonary hypertension.