Fig. 4.
(A) Glucose-stimulated contrast enhanced (GSCE) T1-weighted 3D MR images at 9.4 T of the prostate of TRAMP mice during various stages of tumor development. (Bottom) A typical GSCE pattern of normal healthy prostate in a young TRAMP mouse (age: 10 wk). (Middle) Nascent tumor in dorsal lobe of the prostate showing clear hypointensity due to the presumable lack of intracellular Zn(II) (age: 17 wk). (Top) Poorly differentiated (PD) tumor that originated in lateral lobe and extending to ventral lobe. No GSCE was detected in the tumor, and significant loss of noncancerous prostate was observed (age: 19 wk). Intensity scale bar represents units normalized to highest image intensity as 100%. (B) Average GSCE measured over the entire prostate in three cohorts of animals. P values at the 95% confidence level for NNo lesion = 20, NWD= 5, and NPD = 2.