Table S1.
Constraints for CardioNet flux rate analysis
| Constraint | Control | D2-HG | Source | ||
| LB | UB | LB | UB | ||
| Glucose uptake | 0.294 | 1.316 | 0.372 | 1.610 | This study |
| Oxygen uptake | 1.294 | 80.000 | 60.203 | 78.359 | This study |
| D2-HG uptake | 2.294 | 0.000 | 3.888 | 18.730 | This study |
| Lactate release | 3.294 | 0.046 | 0.099 | 0.109 | This study |
| Glutamine release | 0.000 | Inf | 0.000 | Inf | |
| NH3 release | 0.000 | Inf | 0.000 | Inf | |
| Urate release | 0.000 | Inf | 0.000 | Inf | |
| Glycogen | |||||
| Synthesis | 0.000 | 0.015 | 0.000 | 0.015 | (19) |
| Degradation | 0.000 | 0.136 | 0.000 | 0.136 | (19) |
| Triglyceride turnover | −0.026 | 0.026 | −0.026 | 0.026 | (41) |
| Protein turnover (myosin) | −0.015 | 0.01 | −0.015 | 0.01 | (42) |
Upper and lower bounds for network reactions are given in the table. These bounds define the maximum and minimum allowable fluxes of respective reaction. The stoichiometric matrix and reaction bounds define the solution space of flux distributions of a system, or, in other words, the rates at which every metabolite is consumed or produced by each reaction. Values are given in micromoles per minute per gram dry weight. Inf, Infinite; LB, lower flux bound; and UB, upper flux bound.