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Results from the Rosetta InterfaceAnalyzer and Alanine Scanning
| Right-handed seven start | Left-handed three start | |
| No. of residues in interface | 20 | 44 |
| Buried interface area (Å2) | 1,044 | 1,623 |
| Hydrophobic interface area (Å2) | 514 | 754 |
| Polar interface area (Å2) | 550 | 931 |
| Interface energy (Rosetta units) | −5.92 | −7.50 |
| Alanine scanning hotspot residues | Ser26 | Ile13 |
| Val37 | Gln84 | |
| Ser41 | His105 | |
| Asp235 | Asp107 | |
| Arg236 | Tyr215 | |
| Gln280 | Arg226 | |
| Ser301 | Arg236 | |
| Ile302 | Gln262 |
