Table S4.
Association of parent–offspring relationship with TA and TGCT risk
| Strain | Male parent genotype | Female parent genotype | Male offspring genotype | Phenotype of male parent | No. of males | Cryptorchism | Atrophy | Total TAs | |||
| No. | Frequency, % | No. | Frequency, % | No. | Frequency, % | ||||||
| Comparison between TA-breeders and healthy breeders | |||||||||||
| 129/Sv control strain | With TA | 91 | 7 | 7.7 | 7 | 7.7 | 5 | 5.5 | |||
| Wild-type | Wild-type | Wild-type | None | 270 | 19 | 7.0 | 32 | 11.9 | 20 | 7.4 | |
| A1cf | Wild-type | A1cfKO/+ | Wild-type | With TA | 4 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
| None | 122 | 6 | 4.9 | 6 | 4.9 | 1 | 0.8 | ||||
| A1cfKO/+ | With TA | 3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | |||
| None | 135 | 10 | 7.4 | 9 | 6.7 | 4 | 3.0 | ||||
| A1cfKO/+ | Wild-type | No breeder with TA-affected male parent | |||||||||
| Ago2 | Wild-type | Ago2KO/+ | Wild-type | With TA | 40 | 5 | 12.5 | 5 | 12.5 | 1 | 2.5 |
| None | 75 | 7 | 9.3 | 3 | 4.0 | 4 | 5.3 | ||||
| Ago2KO/+ | With TA | 37 | 0 | 0.0 | 4 | 10.8 | 0 | 0.0 | |||
| None | 54 | 4 | 7.4 | 9 | 16.7 | 1 | 1.9 | ||||
| Ago2KO/+ | Wild-type | Wild-type | With TA | 45 | 2 | 4.4 | 3 | 6.7 | 0 | 0.0 | |
| None | 99 | 8 | 8.1 | 13 | 13.1 | 6 | 6.1 | ||||
| Ago2KO/+ | With TA | 46 | 2 | 4.3 | 3 | 6.5 | 0 | 0.0 | |||
| None | 107 | 10 | 9.3 | 14 | 13.1 | 5 | 4.7 | ||||
| Comparison between TGCT-breeders and healthy breeders | |||||||||||
| 129/Sv control strain | With TGCT | 19 | 2 | 10.5 | 3 | 15.8 | 0 | 0.0 | |||
| Wild-type | Wild-type | Wild-type | None | 361 | 26 | 7.2 | 39 | 10.8 | 25 | 6.9 | |
| A1cf | Wild-type | A1cfKO/+ | Wild-type | With TGCT | 21 | 1 | 4.8 | 0 | 0.0 | 1 | 4.8 |
| None | 126 | 6 | 4.8 | 6 | 4.8 | 1 | 0.8 | ||||
| A1cfKO/+ | With TGCT | 30 | 0 | 0.0 | 1 | 3.3 | 0 | 0.0 | |||
| None | 138 | 10 | 7.2 | 9 | 6.5 | 4 | 2.9 | ||||
| A1cfKO/+ | Wild-type | Wild-type | With TGCT | 16 | 2 | 12.5 | 1 | 6.3 | 0 | 0.0 | |
| None | 107 | 13 | 12.1 | 3 | 2.8 | 5 | 4.7 | ||||
| A1cfKO/+ | With TGCT | 14 | 0 | 0.0 | 2 | 14.3 | 3 | 21.4 | |||
| None | 136 | 8 | 5.9 | 4 | 2.9 | 3 | 2.2 | ||||
| Ago2 | Wild-type | Ago2KO/+ | Wild-type | With TGCT | 6 | 0 | 0.0 | 1 | 16.7 | 0 | 0.0 |
| None | 115 | 12 | 10.4 | 8 | 7.0 | 5 | 4.3 | ||||
| Ago2KO/+ | With TGCT | 12 | 0 | 0.0 | 2 | 16.7 | 2 | 16.7 | |||
| None | 91 | 4 | 4.4 | 13 | 14.3 | 1 | 1.1 | ||||
| Ago2KO/+ | Wild-type | No breeder with TGCT-affected male parent | |||||||||
Occurrence of males affected with a TA or a TGCT in 129/Sv controls and in A1cfKO/+ and Ago2KO/+ heterozygous and wild-type sibling males of reciprocal backcrosses in breeders with a TA-affected or a TGCT-affected male parent and breeders with a male parent with healthy testes.