Figure 3.

Impaired growth in the Psi knockdown wing is sensitive to MED abundance. (A and B) Co-knockdown of the kinase module subunits (CDK8 or CycC) suppressed the Psi RNAi wings up phenotype. (C and D) MED18 RNAi alone reduced wing area (P = 0.0074) but co-knockdown did not significantly alter the Psi phenotype. Psi knockdown in the wing was suppressed by overexpression of MED4, MED7, MED17, MED19, MED20, MED30 and MED31. Overexpression of certain core MED subunits alone (MED4, MED18, MED31) also increased wing size.