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Model for PABP-stimulated translation termination. In the presence of PABP, eRF3a binds efficiently to preTCs and optimally positions eRF1 in the ribosomal complex for stop codon recognition. Accordingly, the termination efficiency is high as indicated by more efficient peptide release. When PABP is pre-bound to the mRNA, it recruits eRF1/3a to the preTCs, thus increasing the local eRF1/3a concentration and stabilizing the eRF binding to the ribosome.
