Table 1. Detectable and not detectable HERV-K HML-2 proviruses based on multiple melt curve analysis (adapted from Subramanian et al. 6).
| Locus | Coordinates (hg19) Chr:Start-End | Name | Orient. | Estim. Age | ORFs | LTR Type | Detected |
|---|---|---|---|---|---|---|---|
| 1p31.1 | 1:75842771–75849143 | K4, K116, ERVK-1 | (+) | <2 | gag | Hs | − |
| 1p34.3 | 1:36955490–36956728 | (−) | N/A | Hs | − | ||
| 1p36.21a | 1:12840260–12846364 | (−) | N/A | gag | 5B | + | |
| 1p36.21b | 1:13458305–13467826 | K(OLDAL023753), K6, K76 | (+) | 22.47–40.68 | gag | 5B | + |
| 1p36.21c | 1:13678850–13688242 | K6, K76 | (+) | 22.69–41.09 | gag | 5B | + |
| 1q21.3 | 1:150605284–150608361 | (−) | N/A | Hs | − | ||
| 1q22 | 1:155596457–155605636 | K102, K(C1b), K50a, ERVK-7 | (−) | <2 | Hs | + | |
| 1q23.3 | 1:160660575–160669806 | K110, K18, K(C1a), ERVK-18 | (+) | 7.81–14.14 | Hs | + | |
| 1q24.1 | 1:166574603–166580258 | K12 | (−) | 14.17–25.65 | 5B | − | |
| 1q32.2 | 1:207808457–207812636 | (−) | N/A | Hs | − | ||
| 1q43 | 1:238925595–238927773 | (−) | N/A | 5B | − | ||
| 2q21.1 | 2:130719538–130722209 | (−) | N/A | Hs | − | ||
| 3p12.3 | 3:75600465–75609150 | (+) | N/A | 5A | − | ||
| 3p25.3 | 3:9889346–9896236 | K11, ERVK-2 | (−) | 12.13–21.96* | Hs | − | |
| 3q12.3 | 3:101410737–101419859 | K(II), ERVK-5 | (+) | 5.51–9.98 | Hs | + | |
| 3q13.2 | 3:112743479–112752282 | K106, K(C3), K68, ERVK-3 | (−) | <2 | gag | Hs | + |
| 3q21.2 | 3:125609302–125618416 | K(I), ERVK-4 | (+) | 4.8–8.69 | Hs | + | |
| 3q24 | 3:148281477–148285396 | ERVK-13 | (−) | N/A | gag | Hs | + |
| 3q27.2 | 3:185280336–185289515 | K50b, K117, ERVK-11 | (−) | <2 | gag, pol | Hs | + |
| 4p16.1a | 4:9123515–9133075 | K17b | (+) | 16.84–30.49 | 5A | − | |
| 4p16.1b | 4:9659588–9668650 | K50c | (+) | 17.19–31.13 | 5A | − | |
| 4p16.3a | 4:234989–239459 | (+) | N/A | 5B | + | ||
| 4p16.3b | 4:3980069–3988631 | K77 | (−) | 11.1–20.1 | 5A | − | |
| 4q13.2 | 4:69463709–69469223 | (+) | 17.09–30.95 | env | 5A | − | |
| 4q32.1 | 4:161579938–161582360 | (+) | N/A | Hs | − | ||
| 4q32.3 | 4:165916840–165924068 | K5, ERVK-12 | (+) | 9.24–16.73 | Hs | − | |
| 4q35.2 | 4:191027414–191034701 | (−) | 13.07–23.67 | 5A | − | ||
| 5p12 | 5:46000159–46010002 | (−) | 13.39–24.24 | Hs | + | ||
| 5p13.3 | 5:30487114–30496205 | K104, K50d | (−) | 6.32–11.44 | Hs | + | |
| 5q33.2 | 5:154016502–154024214 | K18b | (−) | 13.03–23.6 | env | 5A | − |
| 5q33.3 | 5:156084717–156093896 | K107/K10, | (−) | <2 | gag, pol | Hs | + |
| 6p11.2 | 6:57623896–57628704 | K23 | (+) | 9.38–16.99 | 5A | − | |
| 6p21.1 | 6:42861409–42871367 | K(OLDAL035587), | (−) | 9.83–17.81 | 5B | + | |
| 6p22.1 | 6:28650367–28660735 | K(OLDAL121932), | (+) | 19.55–35.4 | Hs | − | |
| 6q14.1 | 6:78427019–78436083 | K109, K(C6), | (−) | <2 | gag, env | Hs | + |
| 6q25.1 | 6:151180749–151183574 | (+) | N/A | env | 5B | − | |
| 7p22.1a | 7:4622057–4631528 | K108L, K | (−) | <2 | pol, env | Hs | + |
| 7p22.1b | 7:4630561–4640031 | K108R, ERVK-6 | (−) | <2 | pol, env | Hs | + |
| 7q11.21 | 7:65469689–65472384 | (−) | N/A | 5B | − | ||
| 7q22.2 | 7:104388369–104393266 | ERVK-14 | (−) | N/A | gag | Hs | + |
| 7q34 | 7:141450926–141455903 | K(OLDAC004979), | (−) | N/A | gag | Hs | + |
| 8p22 | 8:17765202–17773940 | (−) | N/A | HML11 | − | ||
| 8p23.1a | 8:7355397–7364859 | K115, ERVK-8 | (−) | 4.87–8.82* | gag, pol, env | Hs | + |
| 8p23.1b | 8:8054700–8055725 | K27 | (+) | 16.09–29.13 | 5A | − | |
| 8p23.1c | 8:12073970–12083497 | (−) | 15–27.17 | 5A | − | ||
| 8p23.1d | 8:12316492–12326007 | KOLD130352 | (−) | 15.22–27.56 | 5A | − | |
| 8q11.1 | 8:47175650–47183661 | K70, K43 | (−) | 23.46–42.48 | 5A | − | |
| 8q24.3a | 8:140472149–140475236 | (−) | N/A | Hs | − | ||
| 8q24.3b | 8:146246648–146254211 | K29 | (−) | 12.33–22.33 | env | 5A | − |
| 9q34.11 | 9:131612515–131619736 | K31 | (+) | 12.43–22.51 | 5A | + | |
| 9q34.3 | 9:139674766–139684228 | K30 | (−) | 15.46–28 | 5B | − | |
| 10p12.1 | 10:27182399–27183380 | K103, K(C10) | (+) | 1.61–2.91 | gag, pol | Hs | + |
| 10p14 | 10:6867109–6874635 | K(C11a), K33, | (−) | 7.36–13.32 | Hs | + | |
| 10q24.2 | 10:101580569–101587716 | ERVK–17, c10_B | (−) | N/A | gag | Hs | + |
| 11p15.4 | 11:3468656–3478209 | K7 | (−) | 15.44–27.95 | 5A | + | |
| 11q12.1 | 11:58767448–58773196 | (+) | N/A | env | 5B | − | |
| 11q12.3 | 11:62135963–62150563 | K(OLDAC004127) | (−) | 19.46–35.24* | pol | Hs | + |
| 11q22.1 | 11:101565794–101575259 | K(C11c), K36, | (+) | <2 | pol | Hs | + |
| 11q23.3 | 11:118591724–118600883 | K(C11b), K37, | (−) | 13.35–24.18 | gag | Hs | + |
| 12p11.1 | 12:34772555–34782217 | K50e | (−) | 39.23–71.02 | 5A | − | |
| 12q13.2 | 12:55727215–55728183 | (+) | <2 | gag, pol | Hs | + | |
| 12q14.1 | 12:58721242–58730698 | K(C12), K41, | (−) | <2 | gag, pol, env | Hs | + |
| 12q24.11 | 12:111007843–111009325 | (+) | N/A | Hs | − | ||
| 12q24.33 | 12:133667120–133673132 | K42 | (−) | 7.07–12.81 | 5A | − | |
| 14q11.2 | 14:24480625–24484121 | K(OLDAL136419), | (−) | 11.98–21.69 | gag | 5A | − |
| 14q32.33 | 14:106139659–106142540 | (+) | N/A | 5A | − | ||
| 15q25.2 | 15:84829020–84832364 | (+) | N/A | 5B | − | ||
| 16p11.2 | 16:34231474–34234142 | (+) | N/A | Hs | − | ||
| 16p13.3 | 16:2976160–2977661 | K(OLDAC004034 | (+) | N/A | 5B | − | |
| 17p13.1 | 17:7960357–7967219 | (+) | N/A | HML11 | − | ||
| 19p12a | 19:20387400–20397512 | K52 | (+) | 29.71–53.79* | 5B | + | |
| 19p12b | 19:21841536–21841542 | K113 | (−) | <2 | gag, pol, env | Hs | + |
| 19p12c | 19:22757824–22764561 | K51 | (+) | 12.96–23.47* | Hs | − | |
| 19p13.3 | 19:385095–387637 | ERVK-22 | (+) | N/A | Hs | − | |
| 19q11 | 19:28128498–28137361 | K(C19), ERVK- | (−) | N/A | gag, env | Hs | + |
| 19q13.12a | 19:36063207–36067434 | (−) | N/A | Hs | − | ||
| 19q13.12b | 19:37597549–37607066 | K(OLDAC012309), | (−) | 22.87–41.42* | Hs | + | |
| 19q13.41 | 19:53248274–53252591 | (−) | N/A | pol | 5B | + | |
| 19q13.42 | 19:53862348–53868044 | LTR13 | (+) | N/A | env | 5B | − |
| 20q11.22 | 20:32714750–32724384 | K(OLDAL136419), | (+) | 15.74–28.5 | 5B | − | |
| 21q21.1 | 21:19933916–19941962 | K60, ERVK-23 | (−) | 3.46–6.27 | Hs | + | |
| 22q11.21 | 22:18926187–18935307 | K101, K(C22), | (+) | 1.84–3.34 | Hs | + | |
| 22q11.23 | 22:23879930–23888810 | K(OLDAP000345), | (+) | 21.64–39.18* | gag | 5B | + |
| Xq11.1 | X:61959549–61962054 | (+) | N/A | env | 5B | − | |
| Xq12 | X:65684132–65686184 | (−) | N/A | 5A | − | ||
| Xq28a | X:153817163–153819562 | K63 | (+) | N/A | gag | 5B | − |
| Xq28b | X:153836675–153844015 | K63 | (−) | 14.65–26.52 | gag | 5B | − |
| Yp11.2 | Y:6826441–6833384 | (−) | N/A | 5A | − | ||
| Yq11.23a | Y:26397837–26401035 | (−) | N/A | 5B | − | ||
| Yq11.23b | Y:27561402–27564601 | (+) | N/A | 5B | − |