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. 2016 Sep 19;6:33574. doi: 10.1038/srep33574

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Copyright © 2016, The Author(s)

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(A–H) Transformation of hard exudates (from round type to irregular type). Case 3 with diabetic retinopathy at the first examination (A,E), one month later (B,F), two months later (C,G) and four months later (D,H). White squares in color fundus photograph indicate imaged regions in adaptive optics scanning laser ophthalmoscopy (AO-SLO) (A–D). Hard exudates were observed as the round type by AO-SLO (E) at the first examination. After four months, the round type of hard exudates had transformed to the irregular type (yellow arrow) (H). (I) When the round type of hard exudate transformed into the irregular type, the area of hard exudates also decreased (n = 8, P = 0.006, Student t-test).