Table 1. Morphological and hemodynamic characteristics of sham-operated rats (SO), ramipril-treated SO rats (SO-ramipril), rats with myocardial infarction (MI) and ramipril-treated MI rats (n = 6).
| Characteristics | SO | MI | SO-ramipril | MI-ramipril |
|---|---|---|---|---|
| BW (g) | 270.63 ± 25.09 | 285.50 ± 12.50 | 271.0 ± 20.25 | 284.13 ± 23.81 |
| HW/BW (mg/g) | 3.60 ± 0.19 | 4.91 ± 0.20*** | 3.20 ± 0.21 | 3.96 ± 0.17††† |
| LVW/BW (mg/g) | 2.34 ± 0.10 | 3.84 ± 0.15*** | 2.29 ± 0.10 | 2.99 ± 0.11†† |
| HR (/min) | 418 ± 45.7 | 406 ± 39.1 | 415 ± 36.7 | 428 ± 33.4 |
| SBP (mmHg) | 245.1 ± 22.3 | 132.5 ± 24.6** | 189.0 ± 20.8 | 164.9 ± 20.4 |
| DBP (mmHg) | 210 ± 22.1 | 102 ± 13.4** | 141 ± 26.1 | 145 ± 7.9 |
| LVSP (mmHg) | 256 ± 21.5 | 187 ± 5.6* | 243 ± 18.6 | 201 ± 19.5† |
| LVEDP (mmHg) | 46 ± 1.2 | 69 ± 5.7** | 40 ± 4.1 | 34 ± 5.2† |
| +dp/dtmax (mmHg) | 5627 ± 556 | 3879 ± 435** | 5356 ± 421 | 4573 ± 368†† |
| −dp/dtmax (mmHg) | 5561 ± 341.2 | 3531 ± 668.4** | 6170 ± 612.7 | 3346 ± 221.2† |
BW, body weight; HW, heart weight; LVHW: left ventricular heart weight; HR, heart rate, SBP, systolic blood pressure; DBP, diastolic blood pressure; +dP/dt, maximal rate of rise of blood pressure in ventricle chamber; −dP/dt, maximal rate of rise of blood pressure in ventricle chamber; LVESP: left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure. *P < 0.05, **P < 0.01, ***P < 0.001, compared with SO group; †P < 0.05, ††P < 0.01, †††P < 0.001, compared with MI group.