Table 1. Recipient survival after treatment with imDex and/or Tregs (log-rank test).
Treatment | Median survival (days) | Individual Survival (days) | p value |
---|---|---|---|
Untreated△ | 10 | 6 × 2, 9 × 2, 10, 11, 13, 16 × 2 | |
1 μg imDex BN | 10 | 7, 8, 9 × 2, 10, 12 × 2, 13, 14 | =0.5419a |
10 μg imDex BN | 17 | 9 × 3, 12, 17 × 2, 19, 21 × 2 | =0.0241a, =0.0087b |
20 μg imDex BN | 37 | 14, 17 × 2, 21, 37, 47, 49, 52, 53 | <0.0001a, =0.007d |
40 μg imDex BN | 25 | 12, 15, 16, 19, 25, 29, 31 × 2, 33 | = 0.0008a, =0.0498b |
80 μg imDex BN | 26 | 12, 14 × 2, 21, 26, 27 × 2, 29, 31 | =0.0011a, =0.0441b |
20 μg imDex Lewis | 14 | 7 × 2, 8, 10, 14 × 2, 17 × 2, 19 | =0.1754a, =0.0011b |
20 μg imDex F344 | 15 | 7, 9, 10, 14, 15, 16 × 2, 24, 25 | =0.1159a, =0.0041b |
Tregs fresh | 18 | 6, 8, 14, 18 × 2, 24 × 2, 31, 32 | =0.0081a, =0.01c |
Tregs BN-specific | 34 | 17, 18, 27, 29, 34 × 2, 42, 45, 47 | <0.0001a, =0.0083d |
Tregs F344-specific | 19 | 11 × 2, 13, 15, 19 × 2, 26, 27 × 2 | =0.006a, =0.00321c |
20 μg imDex BN/Tregs fresh | 47 | 14 × 2, 16, 36, 47, 49, 56, 58, 60# | =0.0005a, =0.283b, =0.0386d |
20 μg imDex BN/Tregs BN-specific | >100 undifined | 28, 31, 33, 100# × 6 | <0.0001a |
Lewis recipients were transplanted with BN livers. Recipients were treated with imDex and/or Tregs.
ΔTreated with physiological saline.
aCompared with untreated rats.
bCompared with 20 μg imDex BN.
cCompared with Lewis Tregs BN-specific.
dCompared with 20 μg imDex BN/Lewis Tregs (BN-specific).
#Not dead on the day we analyzed data.