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| Ligand | Receptor Isoform |
|
|---|---|---|
| CB1 (nM) | CB1b (nM) | |
| Rimonabant | 2.30 ± 0.69 | 7.65 ± 3.79 |
| (R2 = 0.973) | (R2 = 0.984) | |
| JD-5037 | 8.16 ± 1.51 | 0.24 ± 0.12 |
| (R2 = 0.994) | (R2 = 0.824) | |
The Ki of rimonabant and JD-5037 for the CB1 and CB1b receptors as determined on the CHO-CB1 and CHO-CB1b open tubular columns, respectively, using frontal affinity chromatographic techniques.
