Table 1. Patient characteristics.

Patient	Gender	Age [y]	Smoking status	TNM	Tumor tissue			Plasma
					Mutation	EGFR T790M	No. samples	EGFR sens. mut. (No. pos. samples)	EGFR T790M (No. pos. samples)
1	m	56	non smoker	cT4 cN0 cM1b	EGFR c.2235_49del	unk	10	9	n.d.
2	f	54	fmr. smoker; 35 pys	cT4 cN3 cM1b	EGFR L861Q	neg	9	9	1
3	m	68	fmr. smoker; 35 pys	cT2b cN2 cM1a	EGFR L858R	neg	11	6	4
4	f	61	cur. smoker; 20 pys	cT4 cN2 cM1b	EGFR c.2236_50del	unk	6	1	0
5	f	55	fmr. smoker	cT2A cN0 cM1b	EGFR c.2236_50del	unk	3	1	1
6	f	73	non smoker	pT1 pN1 pM0 R0	EGFR L858R	unk	4	4	0
7	f	57	fmr. smoker; 28 pys	pT3 pN9 pM1a R0	EGFR L858R	neg	6	0	0
8	f	68	non smoker	cT2A cN1 cM1b	EGFR L858R	unk	10	5	1
9	f	73	non smoker	cT4 cN2 cM1a	EGFR c.2235_49del	unk	11	6	0
10	f	60	non smoker	cT3-4 cN3 cM1b	EGFR c.2236_50del	neg	8	2	1
11	f	73	non smoker	cT2-3 cN2 cM1a	EGFR L858R	unk	9	7	0
12	m	56	cur. smoker; 25 pys	cT1a cN2 cM1b	EGFR c.2129 A > G; KRAS G12C	unk	5	5 (KRAS)	0
13	f	60	non smoker	pT1B pN1 pM0 R0	EGFR c.2236_50del	neg	3	3	3
14	m	50	fmr. smoker; 2 pys	cT4 cN3 cM1b	EGFR L858R	pos	2	2	2
15	f	45	non smoker	pT4 pN2 cM0 R1	EGFR c.2235_49del	pos	5	4	3
16	f	59	cur. smoker; 43 pys	cT4 cN3 cM1b	EGFR c.2235_49del	unk	5	2	1

(No.: number; y: years; sens.: sensitizing; pos: positive; m: male; f: female; fmr.: former; cur.: current; pys: packyears; unk: unknown; neg: negative; n.d. = not done).