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. 2016 Sep 19;6:33527. doi: 10.1038/srep33527

Figure 3. HT/PCy enriched diet reduces the severity of mid-stage OA in DMM mice.

Figure 3

Mice (n = 6 per group) underwent sham surgery or DMM bilaterally. Mice received regular diet (Sham and Std groups) or diet supplemented with GlcN, HT/PCy for 12 weeks starting 4 weeks before surgery. Safranin O staining (A) and OARSI score (B) of sham or standard diet (Std), GlcN and HT/PCy diet groups at 8 weeks post-DMM. Immunohistochemical staining (brown signal) using antibody directed against NITEGE for the detection of aggrecan cleavage in sham or DMM mice receiving diet supplementation with GlcN, HT/PCy (C) and relative NITEGE staining intensity (D). *p < 0.05 compared to standard group, #p < 0.05 compared to sham group. Bar represents 250 μm (A) and 50 μm (C).