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. 2016 Sep 19;6:33527. doi: 10.1038/srep33527

Figure 5. HT/PCy supplementation reduces the severity of mid-stage OA in ACLT rabbits.

Figure 5

Rabbits (n = 6 per group) underwent ACLT of the right knee. NaCl (Std), GlcN or HT/PCy were orally administrated every two days for 13 weeks starting 3 weeks before surgery. HES staining of cartilage (A) and OARSI scores (B) of non-operated knee (control) or operated knee (ACLT) at 10 weeks post-surgery are shown. Immunohistochemical detection of aggrecan epitopes (NITEGE) (C) and relative staining intensity of the articular cartilage matrix (D) of standard diet (Std), GlcN and HT/PCy diet groups at 10 weeks after ACLT. (i) Non calcified-cartilage, (ii) calcified cartilage and (iii) sub-chondral bone. *p > 0.05 compared to non-operated knee (control) within the same group; #p > 0.05 compared to ACLT receiving NaCl (Std) group, $p > 0.05 compared to ACLT receiving GlcN. Bar represents 250 μm (A) and 100 μm (C).