Table 1.
Basic information on the papers included for qualitative analysis
| Paper | Aetiology | Study design | Targeted skin layer | Patients (n) | Assessment | SIGN score | LESS score |
|---|---|---|---|---|---|---|---|
| Adcock et al. 2001 [23] | Pig skin | RCT | Hypodermis | 4 | Intra-dermal tonometry | ++ | 17 |
| Adcock et al. 1998 [1] | Pig skin | RCT | Dermis/hypodermis | 12 | Histology | ++ | 16 |
| Revuz et al. 2002 [19] | Ageing skin | CCT | Dermis | 24 | Subjective assessment of skin laxity and skin loosening, stereophogrammetry, cutometer | ++ | 16 |
| Moseley et al. 2007 [24] | Scar-like | RCT | Dermis/hypodermis | 10 | Likert scale, tonometry | ++ | 16 |
| Bourgeois et al. 2008 [27] | Scars | RCT | Epidermis/dermis | 20 | Subjective assessment of pain, itch, tightness, erythema and skin smoothening, profilometry | ++ | 13 |
| Lucassen et al. 1997 [15] | Healthy skin | Pre/post | Dermis/hypodermis | 19 | High-frequency ultrasound | + | 13 |
| Watson et al. 1999 [2] | Healthy skin | RCT | Epidermis/dermis | 5 | Laser-Doppler imaging, lymphoscintigraphy, venous flowmetry | + | 13 |
| Ortonne et al. 2003 [26] | Lipodystrophy | RCT | Dermis/hypodermis | 30 | High-frequency ultrasound, fringe projection, skin fold thickness | + | 13 |
| Innocenzi et al. 2003 [21] | Lipodystrophy | CCT | Epidermis/dermis | 15 | Quantitative histology | + | 11 |
| Monteux et al. 2008 [13] | Lipodystrophy | Pre/post | Dermis/hypodermis | 9 | Skin fold thickness | + | 11 |
| Marques et al. 2011 [16] | Healthy skin | Pre/post | Hypodermis | 12 | Gene profiling, micro-array | + | 11 |
| Innocenzi et al. 2002 [20] | Lipodystrophy | CCT | Epidermis/dermis | 12 | Descriptive histology | + | 10 |
| Scuderi et al. 2008 [28] | Healthy skin | RCT | Epidermis/dermis | 10 | Subjective assessment of skin smoothening and skin tone | 0 | 10 |
| Majani et al. 2013 [18] | Scars | Pre/post | Epidermis/dermis | 26 | Subjective assessment of skin smoothness, pain, tenderness, oedema and aesthetic improvement, histology | 0 | 10 |
| Marquez-Rebollo 2014 [17] | Scar-like | Pre/post | Epidermis/dermis | 70 | Number of indurations | 0 | 10 |
| Gavroy et al. 1996 [22] | Scars | CCT | Details not available | 606 | Test de glissement | 0 | 7 |
| Lattarulo et al. 2001 [14] | Healthy skin | Pre/post | Epidermis/dermis | 34 | Laser-Doppler imaging, tcpO2 | 0 | 7 |
| Worret et al. 2004 [3] | Scar-like | Pre/post | Dermis | 10 | Subjective assessment of pain, colour and elasticity, Quality of Life, cutometer | 0 | 7 |
| Delprat et al. 1995 [12] | Scars | Pre/post | Details not available | 132 | Test de glissement | 0 | 5 |
RCT randomised controlled trial, CCT controlled clinical trial, tcpO2 transcutaneous oxygen pressure