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. 2016 May 4;24(10):1473–1478. doi: 10.1038/ejhg.2016.37

Figure 3.

Figure 3

Haplotype structure of the flanking region of the AICDA gene in the 31 Finnish carriers of p.(Met139Thr) variant. The haplotypes of the carriers analyzed by genotyping chip (the Finnish Twin Cohort study, the National Finrisk Study and the Migraine Family Study) are shown on horizontal lines on yellow background in the top part of the panel. The haplotypes of the carriers analyzed by WES (SISu project and study subjects of family I) are presented on blue background. The red column shows the position of the p.(Met139Thr) variant. Missing genotypes are marked by ‘-'. The yellow/blue squares show the identified shared haplotype in each mutation carrier, white filling indicates noninformative genotypes and black squares label recombination event (ie, absence of the allele included in the above mentioned haplotype). The minimum regions shared by all mutation carriers in each data set are indicated by darker color. aThe markers used in the analysis are indicated with numbers in the top row (marker names listed in Supplementary Table 3). bThe columns framed by black lines highlight the markers shared by both data sets, and the alleles seen in the shared haplotype are shown above the column.