Table 1.

Analysis of distance traveled data to determine time of peak effect and duration of action after 0.56 mg/kg METH challenge doses in vehicle- and mAb7F9-mAb4G9 treated rats in Phase 1 studies.

			Time of Peak Effect (min ± SD)		Duration of Action (min ± SD)
Day	Vehicle or mAbDose #	Time of METH Challenge after Vehicle or mAb	Vehicle	mAb	Vehicle	mAb
−4		Pre-treatment Baseline	35 ± 10	42 ± 20	134 ± 37	140 ± 40
0	1	4 hr post	44 ± 35	15 ± 16	124 ± 38	61 ± 19a
3		3 day post	48 ± 27	27 ± 16	129 ± 31	90 ± 9a
7	2	4 hr post	37 ± 9	18 ± 21	132 ± 39	73 ± 12a
10		3 day post	60 ± 30	20 ± 13a	164 ± 31	105 ± 26a
14	3	4 hr post	44 ± 33	24 ± 11	146 ± 47	74 ± 27a
17		3 day post	54 ± 33	35 ± 18	165 ± 52	106 ± 31a
21		7 day post	69 ± 51	37 ± 13	172 ± 67	141 ± 38

^aStatistical significance compared to time-matched vehicle controls (P < 0.05).