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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Curr Protoc Nucleic Acid Chem. 2016 Sep 1;66:7.24.1–7.24.25. doi: 10.1002/cpnc.12

Figure 7.

Figure 7

CNL-MS3 data-dependent scanning of 4-ABP adducts in human hepatocytes, either (A) untreated or (B) treated with 4-ABP (10 μM). The chromatograms from top to bottom represents: the full scan mode from m/z 400-600; total ion chromatograms of all MS2 scan events; peaks filtered by the CNL of m/z 116, and peaks detected by data-dependent CNL-MS3 scan mode. Spectra in the bottom panel shows the CNL-MS3 products of (C) dG-C8-4-ABP, (D) proposed dG-N2,N4-4-ABP and (E) dA-C8-4-ABP adducts. Reprinted from Bessette (2009) with permission from American Chemical Society.