Fig. 2.

Tumor vasculature characteristics. (A) High and low magnification microscopic images of H&E stained and anti-CD31 stained tumor sections (400–600 mm³). (B) Microvessel density (MVD). (C) Average blood vessel's pore size cutoff (CO) and (D) diameter (DM), of all tested tumor models. The MVD in tumors was assessed by immunohistochemistry as described in the text. CO and DM values were obtained from Refs. [11], [12], [20] and [14], [15], [16], [17], respectively. For MVD analysis, one-way ANOVA was performed using IBM SPSS version 20 followed by Tukey's multiple comparison test (*p < 0.05 and ***p < 0.005).