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. Author manuscript; available in PMC: 2017 Feb 18.
Published in final edited form as: Nature. 2016 Aug 18;536(7616):354–358. doi: 10.1038/nature19095

Figure 4. Relationships between classes 1 and 2.

Figure 4

a) Class 1 (red) and 2 (blue/wheat) were superimposed using ND1+ND3 and viewed along the axis of rotation for ND4+ND5. See ED Table 4 for details of the transformations. b) Change of ~10 Å in the relative positions of B14+SDAPα (hydrophilic domain) and 42 kDa (membrane domain); class 1 in red, viewed from the matrix. c) Loops (ND1 TMH5-6, ND3 TMH1-2, 49 kDa β1-β2 and in 39 kDa) in class 2 that are disordered in class 1, with the ubiquinone-binding site; adjacent TMHs/strands are shown for clarity. The site cannot be detected in class 1 as it appears open. d) Densities for the loop connecting ND3 TMH1-2. For class 1, the loop from the class 2 model (white) was used to identify the density in red.