Table 2.
The mean lifespan of Caenorhabditis elegans (N2) and C. elegans loss-of-function mutants when fed Escheichia coli OP50 on NGM plates containing RES or OXY
| Nematode type | Chemical in NGM | No. of total worms (dead/censored) | MLS ± SE (days) |
|---|---|---|---|
| N2 | DMSO (0.3%, v/v) | 156 (144/12) | 13.5 ± 0.21 |
| Resveratrol (100 µM) | 146 (129/17) | 16.5 ± 0.35*** | |
| Resveratrol (500 µM) | 147 (121/26) | 16.7 ± 0.35*** | |
| Resveratrol (1000 µM) | 144 (105/39) | 17.6 ± 0.23*** | |
| Oxyresveratrol (100 µM) | 142 (110/32) | 14.5 ± 0.32*** | |
| Oxyresveratrol (500 µM) | 144 (114/30) | 15.9 ± 0.31*** | |
| Oxyresveratrol (1000 µM) | 149 (105/44) | 17.7 ± 0.28*** | |
| CF1038 daf-16 (mu86) | DMSO (0.3%, v/v) | 165 (155/10) | 10.8 ± 0.45 |
| Resveratrol (100 µM) | 168 (123/45) | 11.4 ± 0.53*** | |
| Resveratrol (500 µM) | 150 (105/45) | 12.1 ± 0.57*** | |
| Resveratrol (1000 µM) | 150 (105/45) | 12.1 ± 0.61*** | |
| Oxyresveratrol (100 µM) | 130 (119/11) | 12.2 ± 0.58*** | |
| Oxyresveratrol (500 µM) | 166 (110/56) | 12.1 ± 0.60*** | |
| Oxyresveratrol (1000 µM) | 172 (113/59) | 12.3 ± 0.60*** | |
| RB754 aak-2 (ok524) | DMSO (0.3%, v/v) | 201 (176/25) | 11.1 ± 0.45 |
| Resveratrol (100 µM) | 199 (160/39) | 10.8 ± 0.43** | |
| Resveratrol (500 µM) | 201 (149/52) | 10.8 ± 0.47 | |
| Resveratrol (1000 µM) | 200 (142/58) | 10.8 ± 0.47 | |
| Oxyresveratrol (100 µM) | 201 (164/37) | 10.8 ± 0.44 | |
| Oxyresveratrol (500 µM) | 203 (150/53) | 10.5 ± 0.44*** | |
| Oxyresveratrol (1000 µM) | 197 (133/64) | 10.3 ± 0.46*** | |
| VC199 sir-2.1 (ok434) | DMSO (0.3%, v/v) | 171 (134/37) | 11.6 ± 0.55 |
| Resveratrol (100 µM) | 166 (118/48) | 11.4 ± 0.59 | |
| Resveratrol (500 µM) | 163 (113/50) | 11.2 ± 0.60 | |
| Resveratrol (1000 µM) | 183 (136/47) | 11.4 ± 0.54 | |
| Oxyresveratrol (100 µM) | 173 (135/38) | 11.4 ± 0.54 | |
| Oxyresveratrol (500 µM) | 160 (126/34) | 11.5 ± 0.57 | |
| Oxyresveratrol (1000 µM) | 170 (140/30) | 11.1 ± 0.68 |
P value versus control (DMSO); *P < 0.05, **P < 0.01, ***P < 0.001.