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. Author manuscript; available in PMC: 2016 Sep 19.
Published in final edited form as: J Clin Cell Immunol. 2016 Jul 18;7(4):438. doi: 10.4172/2155-9899.1000438

Figure 4.

Figure 4

Effect of inCVAX on T cell infiltration into tumors. Immunohistochemical staining of CD3 (a), CD4 (b), and CD8 (c) was performed in normal liver tissues from control syngeneic wild type C57BL/6 mice and tumor tissues from large HCC-bearing mice with and without inCVAX. Few CD3+, CD4+, and CD8+ T cells were observed in normal mice and large HCC-bearing mice with equivalent level of CD4 and slight increase in HCC-bearing mice. In contrast, inCVAX led to high numbers of CD3+, CD4+, and CD8+ T cells detected in tumor tissues. The average liver- or tumor-infiltrated T cells per 100 fields were calculated. 100× magnification, n=3, *p<0.05, ** p<0.01, error bars represent mean ± SDs.