Figure 6.

Illustration of key metabolic pathways that were altered in the hindbrain of twitcher, an authentic mouse model of Krabbe disease. For simplicity, not all biochemical steps or enzymes involved in the metabolic pathways are shown. We found that glycolysis and gluconeogenesis (A), the pentose phosphate pathway (B), membrane lipid homeostasis (C), and branched-chain amino acid metabolism (D) are all involved in the pathogenesis of the twitcher mice.