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Phenotypic comparison of Krabbe disease
| Phenotype | Human patients | Murine model | Canine model |
|---|---|---|---|
|
| |||
| Irritability | + | − | − |
| Psychomotor regression | + | ? | ? |
| Cerebellar ataxia/intention tremor | + | + | + |
| Postural reaction deficits | + | + | + |
| Stiffness | + | + | + |
| Spastic paresis/paralysis | + | + | + |
| Hearing loss | + | − | + |
| Vision loss | + | − | + |
| Motor and sensory neuropathy | + | + | + |
| Autonomic nervous system dysfunction | + | + | + |
