Table 2. FIC values were determined for each of the drugs selected.
The ΣFIC was calculated as FIC A + FIC B where the combinations are considered synergistic when the ΣFIC value is <0.5, weakly synergistic when ΣFIC is 0.6 to 1.0, additive when ΣFIC is 1.0 to 2.0 and antagonistic when the ΣFIC is >2.
| Inhibitor | DNA damaging agent ΣFIC | ||
|---|---|---|---|
| Mercaptopurine | Hydroxyurea | Phleomycin | |
| W7 | 1.19 | 0.55 | 1.06 |
| Chlorpromazine | 0.73 | 0.88 | 0.94 |
| Vanillin | 0.79 | 1.19 | 1.71 |
| Nu7026 | 0.55 | 0.94 | 0.73 |
| Nu7441 | 0.86 | 1.10 | 1.09 |
| Mirin | 0.73 | 1.05 | 1.01 |
| SCR7 | 0.80 | 0.81 | 0.88 |
| AG14361 | 0.71 | 1.04 | 0.98 |