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. 2016 Sep 13;11:2091–2097. doi: 10.2147/COPD.S106883

Table 3.

Relationships between the SGRQ total score, and CASA-Q domain scores and clinical variables in multivariate analyses

Candidate variables Model 1 Model 2 Model 3 Model 4 Model 5 Model 6 Model 7
CASA-Q cough impact <0.0001 <0.0001 <0.0001
CASA-Q cough symptoms 0.0435 NS 0.00012
CASA-Q sputum impact 0.0581 NS <0.0001
CASA-Q sputum symptoms NS NS 0.0020
FEV1, % 0.0058 0.0024 0.00019 0.0072 0.0068 0.0042
mMRC dyspnea scale <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
Exacerbations 0.0334 0.0266 0.0028 0.0320 0.0046 0.0037
Depression 0.0558 0.0229 0.0037 0.0338 0.0080 0.0017
Anxiety 0.0889 0.0995 0.0331 0.0542 0.0169 0.0090
Cardiovascular comorbidities 0.0072 0.00043 0.0019 0.0167 0.0101 0.0068
Chronic bronchitis 0.0498
R2 0.38 0.60 0.62 0.56 0.58 0.54 0.54

Abbreviations: CASA-Q, cough and sputum assessment questionnaire; FEV1, forced expiratory volume in 1 second; mMRC, modified Medical Research Council dyspnea score from 0 to 4 with higher score indicating more severe dyspnea; NS, not significant; SGRQ, Saint George’s Respiratory Questionnaire ranging from 0 to 100 with lower score indicating more severe health-related quality of life impairment.