Table 4.
Multivariable-adjusted RBC membrane fatty acid levels in current vs. former/never smokers
| Age adjusted | Model 11 | Model 22 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | P value | β | 95% CI | P value | β | 95% CI | P value | |
| Saturated fatty acids | |||||||||
| Palmitic acid (16:0) | 1.64 | 0.71, 2.58 |
0.0006 | 1.77 | 0.78, 2.76 |
0.0005 | 1.73 | 0.73, 2.74 |
0.0007 |
| Stearic acid (18:0) | 0.47 | 0.08, 0.85 |
0.02 | 0.46 | 0.06, 0.87 |
0.02 | 0.42 | 0.004, 0.83 |
0.05 |
| Monounsaturated fatty acids |
|||||||||
| Oleic acid (18:1) | 0.30 | −0.14, 0.73 |
0.19 | 0.24 | −0.22, 0.70 |
0.30 | 0.26 | −0.20, 0.73 |
0.29 |
| Polyunsaturated fatty acids |
|||||||||
| n-6 | |||||||||
| Linoleic acid (18:2n-6) | −0.31 | −0.66, 0.04 |
0.08 | −0.18 | −0.54, 0.18 |
0.33 | −0.14 | −0.51, 0.23 |
0.45 |
| Di-homo-γ -linolenic acid (20:3n-6) |
−0.01 | −0.11, 0.09 |
0.84 | −0.02 | −0.13, 0.09 |
0.69 | −0.008 | −0.12, 0.10 |
0.89 |
| Arachidonic acid (20:4n-6) |
−0.57 | −1.38, 0.24 |
0.17 | −0.87 | −1.73, −0.02 |
0.05 | −0.91 | −1.78, −0.05 |
0.04 |
| Adrenic acid (22:4n-6) | −0.14 | −0.40, 0.12 |
0.29 | −0.35 | −0.63, −0.08 |
0.01 | −0.38 | −0.66, −0.11 |
0.006 |
| Docosapentaenoic acid (22:5n-6) |
0.05 | −0.03, 0.14 |
0.23 | −0.008 | −0.10, 0.08 |
0.85 | −0.02 | −0.11, 0.06 |
0.67 |
| Total n-6 PUFA | −0.64 | −1.83, 0.55 |
0.29 | −1.23 | −2.48, 0.02 |
0.05 | −1.26 | −2.52, −0.003 |
0.05 |
| n-3 | |||||||||
| Eicosapentaenoic acid (20:5n-3) |
−0.38 | −0.54, −0.22 |
<0.0001 | −0.27 | −0.43, −0.11 |
0.001 | −0.26 | −0.42, −0.10 |
0.002 |
| Docosapentaenoic acid (22:5n-3) |
−0.34 | −0.51, −0.17 |
0.0001 | −0.35 | −0.52, −0.17 |
0.0002 | −0.32 | −0.51, −0.14 |
0.0006 |
| Docosahexaenoic acid (22:5n-3) |
−0.94 | −1.29, −0.58 |
<0.0001 | −0.72 | −1.08, −0.35 |
0.0001 | −0.66 | −1.03, −0.24 |
0.0004 |
| Total n-3 PUFA | −1.52 | −2.06, −0.97 |
<0.0001 | −1.26 | −1.82, −0.70 |
<0.0001 | −1.15 | −1.72, −0.59 |
<0.0001 |
| Total n-6 to n-3 ratio | 1.28 | 0.51, 2.05 |
0.001 | 1.07 | 0.27, 1.88 |
0.009 | 0.96 | 0.14, 1.78 |
0.02 |
1
Model 1 adjusted for age, sex, race, body mass index, study site, alcohol use, exercise status, aspirin use, educational status, and post-menopausal status
2
Model 2 adjusted for age, sex, race, body mass index, study site, alcohol use, exercise status, aspirin use, educational status, post-menopausal status, and total energy intake, dietary intake of palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid, α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid.