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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neurosurg Clin N Am. 2016 Oct;27(4):529–535. doi: 10.1016/j.nec.2016.05.009

Figure 1. Stages of Hyperphosphorylated Tau Pathology in CTE.

Figure 1

In stage I CTE, p-tau pathology is restricted to isolated foci in the cerebral cortex, the focal lesions consist of perivascular accumulation of p-tau as neuronal and astrocytic inclusions, with NFTs and dot-like structures.

In stage II CTE, there are multiple p-tau lesions typically found at the depths of the cerebral sulci In stage III CTE, p-tau pathology is widespread in the cortex and the amygdala, hippocampus and entorhinal cortex show neurofibrillary pathology.

In stage IV CTE, there is widespread severe p-tau pathology affecting most regions of the cerebral cortex and the medial temporal lobe, with sparing of the calcarine crtex. All images, CP-13 immunostained 50 μ tissue sections.