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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neurosurg Clin N Am. 2016 Aug 10;27(4):465–472. doi: 10.1016/j.nec.2016.05.006

Box 1.

Possible applications of metabolomics in TBI research

Acute injury setting (in the neurological ICU):
    • Monitoring acute pathophysiology
    • Predicting onset of secondary injuries, such as high ICP, edema, vasospasm, etc.
    • Monitoring treatments: identifying candidate treatments and treatment success
    • Prognosis, long-term outcomes

Chronic injuries:
    • Monitoring evolving pathophysiology
    • Rehabilitation suitablility
    • Association between TBI and later-in-life health issues