Box 1.
Possible applications of metabolomics in TBI research
|
Acute injury setting (in the neurological ICU): |
| • Monitoring acute pathophysiology |
| • Predicting onset of secondary injuries, such as high ICP, edema, vasospasm, etc. |
| • Monitoring treatments: identifying candidate treatments and treatment success |
| • Prognosis, long-term outcomes |
|
Chronic injuries: |
| • Monitoring evolving pathophysiology |
| • Rehabilitation suitablility |
| • Association between TBI and later-in-life health issues |