FIG. 7.

Histomorphological analysis of bone and soft tissue composition in defects grafted within the overall defect area for each group in Cohort I (n = 24 sections) and Cohort II (n = 24 sections). Mean percent area of each tissue for the two groups in each cohort is presented for side-by-side comparison. Bone formation was not different between BMA and DS processing, but DS sites tended to show more vascularity and less fibrosis in the regenerated marrow space. However, the retention of DS processed cells and CTP-Os in the mineralized cancellous allograft matrix was low. In Cohort II, SR sites contained more hematopoietic and vascular tissues and less fibrosis, residual allograft, particularly in the IM cavity, suggesting a more advanced stage of remodeling (p = 0.04). See Supplementary Table S1 (Supplementary Data are available online at www.liebertpub.com/tea) for detailed numeric data.