Table 4.
Factors Associated with Effectiveness by 12 Months
| Variable | Category | 12 month denominator | Do not maintain or return to pre-RT size at 12 months | Maintain or return to pre-RT size at 12 months | P value |
|---|---|---|---|---|---|
| Disease group | 1 Rectal | 15 | 3 (20%) | 12 (80%) | 0.05 |
| 2 Anal | 29 | 9 (31%) | 20 (69%) | ||
| 3 Endometrial | 36 | 3 (8%) | 33 (92%) | ||
| Age | <65 | 60 | 8 (13%) | 52 (87%) | 0.05 |
| ≥65 | 21 | 7 (33%) | 14 (67%) | ||
| Race | Non-white | 21 | 5 (24%) | 16 (76%) | 0.52 |
| White | 60 | 10 (17%) | 50 (83%) | ||
| Education | Less than college degree | 31 | 9 (29%) | 22 (71%) | 0.08 |
| College degree or higher | 50 | 6 (12%) | 44 (88%) | ||
| Marital status | Married | 56 | 7 (13%) | 49 (88%) | 0.06 |
| Other | 25 | 8 (32%) | 17 (68%) | ||
| Menopausal | Pre | 21 | 2 (10%) | 19 (90%) | 0.33 |
| Post | 60 | 13 (22%) | 47 (78%) | ||
| Topical estrogen | No | 79 | 15 (19%) | 64 (81%) | 1.0 |
| Yes | 2 | 0 | 2 (100%) | ||
| Sexually active (baseline) | No | 34 | 8 (24%) | 26 (76%) | 0.39 |
| Yes | 47 | 7 (15%) | 40 (85%) | ||
| Smoking history | No | 41 | 7 (17%) | 34 (83%) | 0.78 |
| Yes | 40 | 8 (20%) | 32 (80%) | ||
| Comorbidities | No | 55 | 11 (20%) | 44 (80%) | 0.76 |
| Yes | 26 | 4 (15%) | 22 (85%) | ||
| Radiation | Pre-operative | 15 | 3 (20%) | 12 (80%) | 0.28 |
| Post-operative | 41 | 5 (12%) | 36 (88%) | ||
| RT with no surgery | 25 | 7 (28%) | 18 (72%) | ||
| RT modality | EBRT | 49 | 12 (24%) | 37 (76%) | 0.14 |
| Intravaginal | 32 | 3 (9%) | 29 (91%) | ||
| No Chemotherapy | No | 54 | 14 (26%) | 40 (74%) | 0.02 |
| Yes | 27 | 1 (4%) | 26 (96%) | ||
| Vaginal moisturizer (3 months) | No | 62 | 13 (21%) | 49 (79%) | 0.50 |
| Yes | 19 | 2 (11%) | 17 (89%) | ||
| Vaginal moisturizer (6 months) | No | 60 | 15 (25%) | 45 (75%) | 0.009 |
| Yes | 21 | 0 | 21 (100%) | ||
| Vaginal moisturizer (12 months) | No | 58 | 12 (21%) | 46 (79%) | 0.54 |
| Yes | 23 | 3 (13%) | 20 (87%) | ||
| Compliance rate by 6 months | Mean (std) | - | 45% (34%) | 68% (28%) | 0.03 |
| Compliance rate by 12 months | Mean (std) | - | 39% (31%) | 57% (27%) | 0.05 |
Abbreviations: EBRT, external beam radiotherapy; RT, radiotherapy.