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A model for SSc induction by Fli-1. In fibroblasts, the phosphorylation of C-Abl by TGF-β induces nuclear translocation of PKCδ. In the nucleus, PKCδ phosphorylates Fli-1 at threonine 312, which initiates acetylation of Fli-1 by PCAF/P300/CBP, resulting in dissociation of Fli-1 from the Col1A2 promoter and transcriptional de-repression. Induction of collagen expression through Fli-1 phosphorylation/acetylation is proposed as a mechanism for SSC.
