Table I.
A list of Fli-1 target genes, suppression/activation effect on these genes, their target cells and mechanistic function with appropriate references.
| Fli-1 target gene | Effect | Target cells | Function | Ref |
|---|---|---|---|---|
| MDM2 | Activation | Erythroid | Cell cycle, apoptosis, genomic instability, cancer | 88 |
| BCL-2 | Activation | Erythroid | Apoptosis, cancer | 87 |
| GATA-1 | Suppression | Erythroid | Cell cycle, cancer | 86 |
| RB | Suppression | Erythroid | Cell cycle, apoptosis, cancer | 20 |
| SHIP-1 | Suppression | Erythroid | Phosphatase, signal transduction, cancer | 92 |
| Several ribosomal genes | Activation | Erythroid | Ribosomal biogenesis, erythroid transformation | 93 |
| NOTCH1 | Activation | T-cells | Signal transduction, cancer | 27 |
| Fli-1 | Activation | T-cells | Transcriptional regulation, hematopoiesis, cancer, vasculogenesis | 25 |
| SCL/TAL1 | Activation | Hematopoietic cells | Hematopoiesis | 49,50 |
| c-mpl, gpIIb, gpIV, gpIX, PF4, NF-E2/p45, MafG, HOxa10 and Rab27B | Activation | Megakaryocytes | Megakaryopoiesis | 29,36 |
| MCP-1 | Activation | Endothelial cells | Chemo-attractant factor | 62 |
| Tek/Tie-2 | Activation | Endothelial cells | Angiogenesis, vasculogenesis | 26 |
| VE-cadherin | Activation | Endothelial cells | Cell junction protein interaction, angiogenesis | 44 |
| VE-Statin/egf17 | Activation | Endothelial cells | Controls the recruitment and proliferation of smooth muscle cells and pericytes | 56 |
| VEGF-A | Activation | Endothelial cells | Angiogenesis, vasculogenesis | 109 |
| COL1A2 | Suppression | Fibroblasts | Involved in construction of type I collagen | 72,73 |