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. Author manuscript; available in PMC: 2016 Sep 19.
Published in final edited form as: Mitochondrion. 2010 Mar 11;10(5):403–410. doi: 10.1016/j.mito.2010.03.002

Figure 1. Spindle defects and chromosome misalignment in oocytes from diabetic mice.

Figure 1

Ovulated MII oocytes from control and diabetic mice were stained with β-tubulin antibody to visualize the spindle (green) and counterstained with TO-PRO to visualize chromosomes (red). MII oocytes from control mice present a typical barrel-shape spindle and well-aligned chromosomes on the metaphase plate. In MII oocytes from diabetic mice, spindle defects (arrows) and chromosome misalignment (arrowheads) were readily observed. Representative confocal sections are shown. Scale bars: 20 µm. (From Wang Q, et al. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol 2009, 23:1603–1612, with minor modifications.)