Table 1.
Baseline demographics and measures of all genotyped patients (N=104) and genotyped patients by COMT rs4680 genotype in the NorCAPITAL trial. Numbers are mean (SD) unless otherwise indicated.
| All | val/val | val/met | met/met | P | |
|---|---|---|---|---|---|
|
Demographics
|
|||||
| N | 104 | 20 | 51 | 33 | |
| Age (years) | 15.4 (1.6) | 15 (1.7) | 15.3 (1.6) | 15.8 (1.4) | 0.16 |
| Female (%) | 72 | 65 | 72 | 76 | 0.70 |
| BMI (kg/m2) | 21.5 (4.1) | 20.3 (4.3) | 22.1 (4.4) | 21.3 (3.5) | 0.24 |
|
| |||||
|
Baseline Measures
|
|||||
| Steps at Week 0 | 4630 (2380) | 4685 (1951) | 4947 (2588) | 4120 (2240) | 0.45 |
| KSQ | 3.7 (0.8) | 3.7 (0.8) | 3.7 (0.9) | 3.5 (0.8) | 0.54 |
| CFQ | 19 (6) | 18 (6) | 20 (6) | 20 (6) | 0.41 |
| FDI | 23 (9) | 20 (8) | 23 (9) | 25 (9) | 0.14 |
| PedsQL | 49 (13) | 53 (12) | 50 (13) | 45 (13) | 0.07 |
| BPI | 4.4 (2.2) | 3.8 (2.6) | 4.2 (2) | 5.1 (2.2) | 0.07 |
| Norepinephrine (nM) | 185 (86) | 159 (80) | 189 (80) | 195 (99) | 0.33 |
| Epinephrine (nM) | 20 (12) | 17 (8) | 22 (14) | 21 (11) | 0.31 |
| SBP supine (mmHg) | 113 (10) | 111 (11) | 114 (10) | 115 (9) | 0.35 |
| SBP standing (mmHg) | 116 (13) | 115 (14) | 115 (14) | 119 (11) | 0.35 |
| DBP supine (mmHg) | 64 (10) | 64 (11) | 64 (11) | 63 (7) | 0.93 |
| DBP standing (mmHg) | 75 (12) | 74 (12) | 75 (12) | 76 (10) | 0.82 |
Abbreviations in alphabetical order: BMI, body mass index; BPI, Brief Pain Inventory; CFQ, Chalder Fatigue Questionnaire; DBP, diastolic blood pressure; FDI, Functional Disability Inventory; KSQ, Karolinska Sleep Questionnaire; PedsQL, Pediatric Quality of Life Inventory; SBP, systolic blood pressure.