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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neurochem Int. 2016 Jun 14;99:72–84. doi: 10.1016/j.neuint.2016.06.009

Fig. 3. Interrelationships of GABA and creatine metabolism.

Fig. 3

Numbered enzymes include: 1, SSADH; 2, arginine-glycine amidinotransferase (AGAT); and 3, guanidinoacetate methyltransferase. The dashed line represents the probable conversion of accumulated GABA to guanidinobutyrate via the action of AGAT, as previously reported (Watanabe et al 1994). Abbreviations: SSA, succinate semialdehyde; GHB, gamma-hydroxybutyrate; GABA, gamma-aminobutyrate; Gly, glycine; Arg, arginine; Orn, ornithine. The structure of guanidinobutyrate is also shown.