Table 1.

Regions showing correlations between μ-opioid receptor availability (MOR BP) and evoked pain brain activity (BOLD). Correlations between MOR BP and BOLD yielded multiple brain regions showing associations of lower MOR BP with lower brain activations. Of note the pgACC/MFG, sgACC, and DLPFC are regions commonly thought to be involved in pain inhibition.

Brain region	MNI coordinates (X Y Z)	Z	Cluster size (mm3)	r value	Peak Voxel R Value	P
MFG	−12, 2, 62	3.89	3224	.80	.80	<.001**
PCC	−8, −44, 40	4.25	888	.80	.84	.036**
pgACC/MFG	−16, 40, 38	4.77	6176	.85	.89	<.001**
Precentral	32, −4, 34	4.17	1240	.77	.83	.004**
DLPFC	−42, 8, 30	3.76	1760	.81	.79	<.001**
MTG	−58, −58, 4	3.59	848	.81	.77	.047**
sgACC	10, 40, −2	4.02	728	.83	.82	.017**
Cerebellum	34, −60, −44	3.91	1144	.81	.81	.008**

^**Whole brain cluster corrected

^*Small volume correction

MFG=medial frontal gyrus, ACC= anterior cingulate cortex, PCC = posterior cingulate cortex, pg = perigenual, DLPFC = dorsolateral prefrontal cortex, sg= subgenual, MTG = middle temporal gyrus