Fig. 2.

FUS-induced MB oscillation and BBBO. (A) Prior to sonication, MBs (red spheres in the capillary lumen) are intravenously administered and disperse in the systemic circulation. (B) When the MBs enter the focus of the ultrasound field, they expand and contract, stimulating the opening of the BBB, thereby allowing therapeutic agents (small purple spheres) to enter the brain parenchyma. Abbreviations: FUS = focused ultrasound, MB = microbubble, BBBO = blood-brain barrier opening. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)