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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2016 Apr 25;171(7):925–930. doi: 10.1002/ajmg.b.32452

Figure 2. Schematic diagram of LRRK2 and codon 1441 mutations.

Figure 2

The functional domains of LRRK2 are depicted (top) together with the location of well-established pathogenic mutations for Parkinson’s disease. The nucleotide (underlined) and corresponding amino change resulting from each of the four mutations that occur in codon 1441 are displayed (bottom), along with the Combined Annotation Dependent Depletion (CADD) score for each mutation.