Table 1.
Clinical Characteristics of Affected Members of the Pedigree
| Characteristic | II-2 | Patient II-3 |
II-4 |
|---|---|---|---|
| Sex | M | F | M |
| Age at onset, yr | 76 | 68 | 45 |
| Age at last evaluation, yr | 78 | 69 | 67 |
| Age at death, yr | – | – | 67 |
| Bradykinesia | Y | Y | Y |
| Rigidity | Y | Y | Y |
| Resting tremor | Y | Y | Y |
| Postural instability | N | Y | Y |
| Unilateral onset | Y | Y | Y |
| Levodopa response | Y | Y | Y |
| Levodopa-induced dyskinesia | N | N | Y |
| Hoehn and Yahr stagea | 2 | 3 | 5 |
| MDS-UPDRS III scorea | 26 | 27 | NA |
| Visual hallucinations | N | N | Y |
| Cognitive statusa | MCI | MCI | NA |
MCI, mild cognitive impairment; MDS-UPDRS III, Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III; NA, not available
a
Determined at last evaluation