Figure 1.

(A) T2 weighted axial MRI of the brain showing severe cerebral atrophy [Grade 4 rating using a published reference template (31)] with sulcal widening (red arrow). (B) Axial MRI of the brain demonstrating a linear gyriform hypointensity (red arrow) on SWI sequence in a cortical distribution representative of superficial siderosis. (C) T2 FLAIR weighted MRI showing large confluent lesions (red arrow) with a Fazekas 3 rating as described in the Section “Materials and Methods.” (D) SWI MIP sequence MRI of the brain showing multiple diffuse microbleeds (red arrow). Microbleeds were assessed using the validated Brain Observer Microbleed Scale (BOMBs) criteria as discussed in the Section “Materials and Methods.”